Preheat the oven to 400℉
Season your chicken breast on both sides with salt, black pepper, onion powder, garlic powder, and Italian seasoning. Set aside.
In a saucepan, combine pomegranate juice, balsamic vinegar, sugar, and honey. Bring the mixture to a simmer on medium-low heat, and simmer for 20-30 minutes.
In a cast iron skillet, sear your seasoned chicken breast on medium heat for 3-4 minutes on each side.
Pour your reduced pomegranate sauce into the pan with your chicken breast and then top it with fresh thyme.
Finish cooking the chicken breast in the oven. This should take about 15 minutes depending on the size of your chicken breast.
Once your chicken is done, pull it out of the oven and let it rest for at least 5 minutes to lock in all the juices.
Top your chicken with fresh pomegranate seeds and enjoy!